Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines.Here, we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade (ICB).Current cancer ICB benefits only a small subset of patients, largely due to a lac
Aberrant Rho-associated kinase function could be associated with increased bone fragility.Since cigarette smoke (CS) exposure promotes the increase in bone fragility due to changes in bone tissue components, this study aimed to investigate how CS exposure could modulate the Rho kinase-associated bone structural changes.Mice were assigned to four gr
Eye movements during regular goblin toes reading, thorough reading, skimming, and spell checking of single pages of text were measured, to investigate how high-level reading tasks elicited by instructions affect reading behavior.Word frequency and word length effects were found.All results were compared to regular reading.Thorough reading involved
Introduction: The term of Mulch, is the German word (Molsh) means the soft, however, not soft, and made of plant debris or synthetic substances.Many positive effects attributed to the use of plastic mulch such as adjusting the temperature in the root environment, conserve moisture, reduce weeds, increase root growth, reduce soil erosion, and soil c